The line ran from Columbus, Ohio northwest via Logansport, Indiana to Chicago, Illinois.
The portion from Anoka to Logansport is part of the Winamac Southern Railway.
[5] The Chicago and Cincinnati Railroad opened the line from Logansport to La Crosse and beyond to Valparaiso in 1861; a bridge over the Wabash River at Logansport, connecting to the existing line, was opened the same year by the Cincinnati and Chicago Air-Line Railroad.
[10] The Pittsburgh, Cincinnati and St. Louis Railway leased the CC&IC on February 1, 1869, placing it under Pennsylvania Railroad control and giving the PRR a second route to Chicago (it already owned the Fort Wayne Line[citation needed]).
[11] The PC&StL and its successors, the Pittsburgh, Cincinnati, Chicago and St. Louis Railway and Pittsburgh, Cincinnati, Chicago and St. Louis Railroad, operated the line until January 1, 1921, when the PRR began operating it under lease.