The unit is based out of Marine Corps Base Camp Lejeune, North Carolina and is in direct support of the 22nd Marine Expeditionary Unit (22nd MEU) .

Provide the MEU with mission-essential combat service support to ensure readiness, sustainment, and mission capability are achieved and maintained.

The unit currently known as CLB-22 traces its history back to Combat Service Support Detachment 23 (CSSD-23), the unit that for years provided combat service support to the 32nd and then 22nd MAUs.

In the fall of 1990, shortly after the 22d MEU's deployment to Liberia where they evacuated more than 2,300 civilians from the war-torn country, MSSG-22 was deployed to Southwest Asia where it served as CSSD-22 during Operation Desert Storm.

In 2003, because of the deployment of the 2nd Force Service Support Group to southwest Asia for Operation Iraqi Freedom, a unique allocation of forces proved necessary to staff MSSG-22 for its 2004 deployment with the 22nd MEU.