To provide general intermediate level supply, field level maintenance, material distribution, procurement management and equipment fielding support to the Marine Expeditionary Force and support to specified Marine Aircraft Wing organizations.

Combat Logistics Regiment 25 was activated 26 May 2006 at Marine Corps Base Camp Lejeune, North Carolina.

Elements of the regiment participated in Operation Iraqi Freedom from February 2007 through January 2008.

As part of the on-going reorganization of the Marine Corps, the regiment was decommissioned on 1 July 2020.

[1] A unit citation or commendation is an award bestowed upon an organization for the action cited.