[4] On 11 June 2021, We Are Messengers released "Come What May" as the lead single to their third studio album, Wholehearted (2021).

[6] On 10 September 2021, We Are Messengers released a new version of the song, titled "Come What May +" featuring Cory Asbury.

Darren Mulligan shared that the song was inspired his parents, saying:[8] They learned that circumstances did not determine their joy or fullness of life.

"Come What May" is composed in the key of F♯ with a tempo of 86.5 beats per minute and a musical time signature of 68.

[10] Jesus Freak Hideout's Joel Zaloum noted that "there's a certain conviction in Mulligan's voice and writing, as of someone who isn't just checking off boxes or using 'Christianese,' but one who's experienced God's forgiveness personally" which made the track "immensely powerful.

"[11] Kelly Meade in her Today's Christian Entertainment's review, said the song is "a faith-filled anthem declaring a trust in the steadiness of Jesus through everything we face in life.

[16] We Are Messengers uploaded the official lyric video of "Come What May" on YouTube on 11 June 2021.