Comic Book Tattoo includes an introduction by another longtime friend of Amos, Neil Gaiman, creator of The Sandman series.

Of her role in the project, editor Hoseley said, "It was very important to [Amos] that she see how the different creators were treating 'her girls' (the songs), but at the same time, not tying the creator's hands or make them feel restricted in any way and making sure that they felt the freedom to tell the kind of story that they felt strongly about.

"[1] When approached to contribute to the project, the graphic artists were asked to create a story that reflects that which the songs make them feel.

About the finished collection, Amos said, "I have been surprised, excited and pleasantly shocked by these comics that are extensions of the songs that I have loved and therefore welcome these amazing stories of pictures and words because they are uncompromisingly inspiring.

* – Song is a B-side from aforementioned album (C) – Artist served as a colorist (L) – Artist served as a letterer Comic Book Tattoo was initially made available in three formats, with the addition of another special edition released in November 2008.