The hosts express their individual opinions in an informal way that many fans think resembles a discussion between friends hanging out at home or at the local comic shop, giving the podcast a unique point of view.

[1][2] Comic Geek Speak has interviewed over 400 creators including Stan Lee, Terry Moore, Jamal Igle, Marv Wolfman, Gene Colan, Dave Sim, Geoff Johns, Matt Fraction, Joe Kubert, Freddie Williams II, Paul Pope, Jonathan Hickman, Denis Kitchen, Sean McKeever, and David Petersen, among many others.

The CGS hosts also regularly visit comic conventions, giving day-to-day overviews of their experiences as attendees, interviewing creators as they promote their upcoming projects, talking to listeners, and even moderating or participating on panels.

When the number of listeners showing up for these recordings outgrew what Golden Eagle could accommodate comfortably, Episode 300 moved to an unoccupied storefront inside the Fairgrounds Square Mall.

Notable guests included Mike Norton, Jamal Igle, David Petersen, Sal Abbinanti of Atomika, Buzz Aw, Morry Hollowell, Danielle Corsetto and many others.