The main focus of the game is the creation of various dōjinshi by the player's character, during which there are varied opportunities to interact with a cast of girls.

Comic Party has spawned both a manga (illustrated by Sekihiko Inui) and an anime series since its inception, as well as a Dreamcast version of the original PC game which added a new character (Subaru) and removed the pornographic elements (reverse-ported to Windows, that version is called "Comic Party DCE").

Diverging frequently from Comic Party canon, this offshoot manga series includes more yaoi elements than the original materials.

It is the player's task to decide the schedule of the main protagonist, Kazuki Sendō, as he prepares for the Comic Party convention that takes place once a month.

How fast Kazuki can complete his dōjinshi, how many copies he can sell at each convention, and what girl he is able to date depends on the player's choices.

At certain points of the conversation, the player will be asked to choose between two or more actions that can affect the feelings of that person you are interacting with and can lead to other events.

Early April, Kazuki Sendō is invited by his friend, Taishi Kuhonbutsu, to come with him to Tokyo Big Sight.

Thirteen episodes and four ten minute specials were produced by Oriental Light and Magic and KSS and directed by Norihiko Sudo.

The anime focuses on the dōjinshi creation part of the game rather than the dating aspect and the specials are an original story involving the cast of Comic Party taking a vacation to a hot spring resort.

[9] On September 4, 2014, North American anime licensor Discotek Media announced that they have acquired the series and will re-release it on DVD in January 2015.

In Comic Party Revolution, Kazuki and Mizuki are now attending college and many of the events that take place in the game are hinted to have happened.

[16][17] In the first episode of the original series, Kazuki has a dream set in the world of To Heart, arguably AQUAPLUS' most famous franchise.

Kazuki is cast in the role of Hiroyuki, and a number of other familiar characters appear, including Akari Kamigishi and LEAF mascot Multi.