Commerce is a Mississippi River village in Scott County, Missouri, United States.

Commerce was one of the few areas in Scott County to have uninterrupted mail service during the Civil War, as guerilla bands elsewhere made delivery unsafe for the northern carriers.

Commerce, along with the German settlement of New Hamburg, were the two enclaves of Union sympathizers in Scott County during the war.

On February 21, 1862, General Pope landed here with 140 troops, but when he left a week later his force consisted of 26,153 men.

Scott County courthouse records were moved to a military post at Cape Girardeau during the Civil War.

In 1878, the county seat was returned to Benton, and the old temporary courthouse brick building then was converted into a grade school.

Around the time in 1875, the Vincent Heisserer saloon building erected in 1867 was converted into a Masonic hall.

Commerce was originally a Methodist town, with a congregation established as early as 1825 and without a Baptist church until 1906.

[5] According to the United States Census Bureau, the village has a total area of 0.35 square miles (0.91 km2), all land.