Commerce Bank & Trust was founded in 1955 and is now a full-service commercial bank with branch offices in Worcester, Holden, Leominster, Marlborough, Milford, Shrewsbury, Webster, West Boylston, Westborough, and, through its recent acquisition of Mercantile Bank & Trust Company, Boston.

The three Mercantile Bank & Trust offices, located in the Fenway, South End, and Brighton sections of Boston, are now operating as branches of Commerce Bank & Trust Company.

The combined organization has assets of $1.93[1] billion and 16 retail banking offices servicing people and businesses across Central and Eastern Massachusetts.

[3] On May 2, 2008, federal Judge F. Dennis Saylor granted a preliminary injunction, prohibiting the use of the TD Commerce name in Massachusetts branches.

In May 2017, Berkshire Hills Bancorp purchased Commerce Bancshares Corp., the parent company of Worcester-based Commerce Bank, in a stock deal valued at a reported $209 million.