It runs from the M31 (Joe Slovo Drive; Sivewright Avenue) to the R41 (Main Reef Road), and is indicated as part of the R24.

[9][10][11] The last remaining shops and restaurants of Johannesburg's first Chinatown are located between buildings 5 and 17 on the western end of Commissioner Street.

It is also getting smaller due to most of the descendants of the original immigrants now being 2nd and 3rd generation South African Chinese who have started to spread out to do business in other parts of the city and country.

[10][12] Due to its long history, a number of buildings on Commissioner Street have reached the requirements to be protected as national or provincial heritage sites.

The proposal was to rename the street after Apartheid struggle leader and founding member of the ANC Women's League, Albertina Sisulu.