Comoé District (French: District du Comoé; pronounced [ko.mo.e], named for the Komoé River) is one of fourteen administrative districts of Ivory Coast.

The district is located in the southeast corner of the country, bordering Ghana to the east, Zanzan District to the north, Lacs District and Lagunes District to the west, and the Atlantic Ocean to the south.

Comoé District was created in a 2011 administrative reorganisation of the subdivisions of Ivory Coast.

[4] The territory of the district was composed by merging the former regions of Moyen-Comoé and Sud-Comoé.

[1] Comoé District is currently subdivided into two regions and the following departments: According to the 2021 census, Comoé District has a population of 1,501,366.