The song was released on July 13, 2021, through Sony Music Latin, as the lead single from Emilia's debut studio album, Tú Crees en Mí?

"Como Si No Importara" peaked at number three on the Billboard Argentina Hot 100 and reached the top 20 in Paraguay and Uruguay.

[1] The official announcement of the single, along with a preview, was posted by Emilia on her social media one day before the release, on July 12, 2021.

"It is rumored that Frank Sinatra stayed in this penthouse during his best moments, and I thought it was ideal for an intimate encounter between the two artists, immersed in a luxurious vintage aesthetic", said Argentine director Martin Seipel, who also produced some of her previous songs like "Perreito Salvaje".

[3][4] On February 24, 2022, Emilia and Duki performed "Como Si No Importara" for the first time at the Premios Lo Nuestro.