In medicine, the Comorbidity–polypharmacy score (CPS) is a measure of overall severity of comorbidities.
[2] This score has been tested and validated extensively in the trauma population, demonstrating good correlation with mortality, morbidity, triage, and hospital readmissions.
[3][4][5] Increasing levels of CPS were associated with significantly lower 90-day survival in the original study of the score in trauma population.
Additionally, CPS considers a wider range of comorbidities than CCI, and assigns the same weight to each.
[2] A study comparing the two metrics found that CCI was a better predictor of mortality than CPS in older trauma patients.