Meléndez was born and raised in Caguas, Puerto Rico, where she received her primary and secondary education.

After graduating from high school she enrolled at the University of Puerto Rico where she earned her teacher's certificate.

She was named director of the Hispanic Studies and Humanities Faculty Department at the University, a position she held between 1940-1959.

Concha Melendez Ramirez, her home from 1940 until her death, which has been designated a National Historic Landmark.

Every year the Coalition of Hispanic American Women of Miami, selects five high school graduates, who will receive the Elena Mederos/Concha Melendez Scholarship for their outstanding academic records.