In the 20th century, the painting was transferred onto canvas using a thermal roller, due to the precarious condition of its original wooden panel.

The painting represents the Virgin Mary enthroned at center, with the Baby Jesus on her lap.

For example, Mary is dressed in red and blue; and Saint Catherine wears a crown and holds the instrument of her martyrdom, a wheel.

At the foot of the throne, two musicians add movement to the Sacra conversazione composition.

Above the throne, the coffered vault opens out onto a blue sky with little white clouds, adding light to the painting.