It was a single-elimination tournament and seeding was based on regular season records.

In April 2022, it was announced that five of its members (Coastal Carolina, Kentucky, Marshall, Old Dominion, and South Carolina) would join the Sun Belt Conference for the fall 2022 season, as would West Virginia, which had previously announced a planned move of men's soccer from the Mid-American Conference to C-USA.

[1] One month later, the remaining four members (Charlotte, FIU, Florida Atlantic, and UAB) announced they would join the American Athletic Conference effective fall 2022.

[2] The top eight (6) teams determined by points following the regular season will qualify for a single-elimination tournament.

Competition dates are set for Wednesday, Friday and Sunday to allow a day between quarterfinals, semifinals and the championship final.