The Edmond J. Safra Synagogue, organized by Congregation Beit Yaakov, is an Orthodox Jewish synagogue located on East 63rd Street off Fifth Avenue in the Upper East Side neighborhood of Manhattan, in New York City, New York, United States.

Noting the absence of a formal synagogue and communal center for the Sephardic Jews of the Upper East Side of Manhattan, he expressed a desire to build a central house of worship in the area.

Dignitaries including the Chief Rabbi of Israel and the then Mayor Michael Bloomberg attended an official inauguration of the building in October 2003.

[4][6] The massive bronze doors with their Tree of Life motif are by American sculptor Mark Beard.

[8] Due to its location in the Upper East Side Historic District, the synagogue design required approval from the New York City Landmarks Preservation Commission, which called it an "artful synthesis of the composition, details and material palette of the Beaux-Arts style, which plays an important role in defining the special architectural character of the Upper East Side Historic District.