In Shelton, Route 110 is designated the Veterans Memorial Highway.

[1] Route 110 begins at an intersection with US 1 in Stratford and heads north along the west bank of the Housatonic River, intersecting Route 15 before continuing into Shelton.

In Shelton, it continues north along the Housatonic River, intersecting Route 8, then turns northwest through the center of town and west to Monroe.

[1] The road from Monroe to Shelton was designated as State Highway 173 in 1922.

The East Main Street portion in Stratford was Route 8A.