It then runs through Colchester center, then goes to the outskirts of Lebanon town as a rural collector road.

Route 16 begins at a junction with Route 66 in the Cobalt section of East Hampton.

In the village of Westchester, it intersects Route 149.

It then meets Route 2 at Exit 18 before reaching Colchester center.

Here it duplexes with Connecticut Route 85 for 0.07 miles, then continues northeasterly toward Lebanon, where it end at a junction with Route 207.