Senator from Texas; Mack's widowed grandmother married Connally the year after Sheppard died.

Mack led the field in a crowded four-way Republican primary with 28 percent of the vote and won a run-off election in October against State Representative Ted Ewing 58% to 42%.

[8] In the general election, Mack defeated Democratic attorney Hugh Rodham (brother of Hillary Clinton) 71% to 29%, winning every county in the state.

During his congressional career, Mack supported[10] the passage of laws dealing with health care, fiscal policies, modification of the tax code, and public housing reform.

[11] Mack led a bipartisan congressional effort to double funding for biomedical research through the National Institutes of Health and worked to secure the necessary appropriations.

[12] He also secured Medicare coverage for clinical trials and was a leading Republican advocate of the Women's Health Initiative.

[14] Mack helped define the framework of legislation to allow the financial industry to respond appropriately to the increasing demands of an aggressive global marketplace.

[15] Democrat Bill Nelson, the Florida State Treasurer and a former U.S. Representative, won the open seat.

Since early 2007, Mack has served as the Senior Policy Advisor to Liberty Partners of Tallahassee, a Florida-based lobbying firm.