Conosa includes the species Dictyostelium discoideum, a social amoeba, and Entamoeba histolytica, a human pathogen, among others.

[5] While morphological characteristics like pseudopodia and body shape, flagella, and cytoplasm properties have not been regarded as convincing taxonomic suggestions,[2] emerging sequencing data is being used to support Conosa’s monophyly.

A study using several hundred phylogenetic markers of 30 species found Conosa to be monophyletic as representatives of Mycetozoa, Entamoebidae, and Pelobionta grouped together using several amino acid sequencing analysis methods.

For example, another study using seven protein-coding genes did not find Conosa to be monophyletic due to members of Lobosa sharing a phylogenetic branch with the Conosan lineage Variosea.

[6] Flabellinia Centramoebia Corycidia Echinamoebia Elardia Cutosea Archamoebea Variosea Dictyostelea Ceratiomyxea Myxogastrea Opisthokonta The last common ancestor of Conosa was likely an aerobic protist with anterior and recurrent flagellum.

[5] A study of the complete proteomic content of 23 eukaryotic genomes found that representative members of Mycetozoa and Archamoebae do share a common ancestor, and their divergence occurred almost as long ago as the split of fungi and animals.