She was the wife of Irish playwright Oscar Wilde and the mother of their two sons, Cyril and Vyvyan.

In 1888, Constance Wilde published a book based on children's stories she had heard from her grandmother, called There Was Once.

[11] According to The Guardian, "theories [about her death] have ranged from spinal damage following a fall down stairs to syphilis caught from her husband.

"[12] Also according to The Guardian, Merlin Holland, grandson of Oscar Wilde, "unearthed medical evidence within private family letters, which has enabled a doctor to determine the likely cause of Constance's demise.

The letters reveal symptoms nowadays associated with multiple sclerosis but apparently wrongly diagnosed by her two doctors".

[11] Writing in The Lancet in 2015, Ashley H. Robins and Merlin Holland surmised that, "the surgery Bossi performed in December 1895 was probably an anterior vaginal wall repair to correct urinary difficulties from a presumed bladder prolapse.

The immediate cause of death is thought to have been severe paralytic ileus, which developed either as a result of the surgery itself or of intra-abdominal sepsis.

In 2022,[14] Emilia Clarke was revealed to be the lead of the biographical film An Ideal Wife by director Sophie Hyde, which will explore the sexual awakening Constance experienced when she discovered that Wilde was a homosexual.