He attended military school in the same class with future Generals Gheorghe Mihail and Nicolae Macici, being promoted after graduation to the rank of second lieutenant (July 1, 1907) and assigned to the 5th Roșiori Regiment.

[2] Colonel Sănătescu was appointed on May 5, 1928, as a military attaché in the Romanian Legation in London, where he remained for two years until June 30, 1930.

He was decorated on November 7, 1941, with the Order of the Star of Romania with swords in the rank of Grand Officer with the ribbon of Military Virtue "for the dexterity with which he led the troops of the Army Corps in the battle of Odessa.

[3] He participated in several meetings with civilians and soldiers close to the Royal House who planned the overthrow of the Antonescu regime, Romania's exit from the anti-Soviet war and turning around the weapons against Nazi Germany.

[3] That evening, Sănătescu was appointed President of the Council of Ministers and formed a military cabinet in which the leaders of the four parties that had supported King Michael had one representative without a portfolio.

[8] The Sănătescu government was entrusted with the important mission of consolidating the coup by repelling the attack of the German contingents in the country.

[9] The Sănătescu government sent a delegation consisting of Prince Barbu A. Știrbey, General Dumitru Dămăceanu, Lucrețiu Pătrășcanu, and Ghiță Popp to negotiate and sign the Armistice Convention in Moscow with the United Nations.

[citation needed] On September 15, a working meeting took place between members of the Sănătescu government and participants in the signing of the armistice during which Iuliu Maniu observed that Romania's negotiators had to "accept points that represent a real capitulation, not a free Armistice contract.

"[citation needed] Also, on September 12, 1944, at the energetic intervention of Sănătescu, Anton Buga, who had been sentenced to death, was released.

Losing the trust of the leaders of the liberal and peasant parties, which perceived him as too moderate towards the communists, Sănătescu submitted his resignation on December 2, 1944.