Dominic Constantine was the eldest son of Theodore Alexander, Prince of Löwenstein-Wertheim-Rochefort (1722–1780) and his wife Catharine Louise Eleonore, Countess of Leiningen-Dagsburg-Hartenburg.

Dominic Marquard was a son of Maximilian Karl Albert, Prince of Löwenstein-Wertheim-Rochefort (1656–1718) and his wife Polyxena Maria, Countess Khuen von Lichtenberg und Belasi.

His father had served as governor of Milan, representing Charles VI, Holy Roman Emperor until his own death.

Ferdinand Karl was a son of Johann Dietrich, Count of Löwenstein-Wertheim-Rochefort (1585–1644) and his first wife Josina von der Marck.

Johann Dietrich was a younger son of Louis III, Count of Löwenstein-Wertheim (1530–1611) and his wife Anna, Countess of Stolberg.