[2] Although born in the United States of America, Alexopoulos studied in Athens until the beginning of high school, when he returned to his birthplace of Chicago in October 1919.

[1][3] Alexopoulos had to move to Greece at an early age to accompany his deployed father who joined the Greek army in the Balkan Wars.

[8][1] Besides the utmost important Introductory Mycology, his work in collaboration with Storck regarding Fungi DNA was also extremely important, as one of the pioneers in comparing the proportion of guanine and cytosine content of Fungi DNA for taxonomic purposes [9] Alexopoulos had 40 students during his academic life, including Master's, doctoral and post-doctoral students.

[2] Among these students was Meredith Blackwell, an emerita Professor at the Louisiana State University who focuses on fungi associated with arthropods,[10] and mycologist O'Neil Ray Collins.

[11] On the upper branches of Alexopoulos' "scientific genealogic tree" lies the Heinrich Anton De Bary[1] known as the Father of Plant Pathology.

[13] Alexopoulos was the last mycologist to be the President of the Botanical Society of America, a landmark of the connection loss between these two fields of science.