[4] Around 1208, he accompanied the deposed Byzantine emperor Alexios III Angelos, who had sought refuge in the Epirote court, to the Sultanate of Rum.
The dispute led to the forcible deposition and exile of Apokaukos in 1220, and was resolved only in May 1221 after a synod including representatives from most of the senior sees in Greece and the Epirote domains.
[7] About 1225, when Theodore was proclaimed emperor at Thessalonica, Constantine and his other surviving brother, Manuel, received the next highest title of Despot.
[8] His activities thereafter are obscure: he probably did not participate in the disastrous Battle of Klokotnitsa in 1230, where Theodore was captured by the Bulgarians.
He remained ruler of Aetolia and Acarnania, owing only a loose allegiance to his brother Manuel, now emperor at Thessalonica.