[1][2] He was born on 10 November 1974 at Parombo, in present-day Nebbi District in the West Nile sub-region, in the Northern Region of Uganda.
[1][3] He was admitted to the Uganda Martyrs' National Major Seminary Alokorum, Gulu District, where he studied philosophy.
Later he obtained the degree of Doctorate in Dogmatic Theology from the Cardinal Stefan Wyszyński University, Warsaw, in Poland.
Father Rupiny served in various roles as a priest of the Roman Catholic Diocese of Nebbi, including as:[4] At the time that he was appointed bishop, he was the rector of the Uganda Martyrs' National Major Seminary, Alokolum.
[5] Bishop Constantine Rupiny will take over the diocese from Archbishop Raphael p'Mony Wokorach, who served as the Apostolic Administrator of Nebbi Diocese since 12 July 2024, when he (Wokorach) the last diocesan bishop, was elevated to his current position as the Archbishop of the Roman Catholic Archdiocese of Gulu.