PS-110 Karachi South-V (پی ایس-110، کراچی جنوبی-5) is a constituency of the Provincial Assembly of Sindh.

The seat became vacant after Imran Ismail resigned for Governor Sindh's post.

By elections were held in the entire constituency on 21 October 2018 and Pakistan Tehreek-e-Insaf's Shahzad Qureshi won the seat in by-polls securing 12,455 votes and PPP Mohammed Fayaaz Pirzada coming second with 6,292 votes.

The entire week, the Muttahida Qaumi Movement (MQM) had been appealing to the Election Commission of Pakistan to hold elections throughout the NA-250 constituency which also included PS-113, but their appeal was rejected.

Samar Ali Khan was declared as the Member of the Provincial Assembly of Sindh from this constituency of Karachi who