This is partly due to several large U.S. government regional centers housed within the Consulate, which provide support in security, construction, and financial matters to several other U.S Diplomatic posts located throughout Europe, the Middle East, and Africa.

In March 2017, a series of documents, referred to as Vault 7, revealed that the US government uses the consulate as a base for cyber operations.

This diplomatic representation was the largest US consulate worldwide regarding personnel and facilities and has played a prominent role in the US government's intelligence architecture for years.

The intelligence personnel, including CIA agents, NSA spies, military secret service personnel, the US Department of Homeland Security employees, and the Secret Service employees are working in the building complex with high walls and barbed wire in the north of the city.

Vault 7 documents reveals the Frankfurt hackers, part of the Center for Cyber Intelligence Europe (CCIE), were given cover identities and diplomatic passports to obfuscate customs officers to gain entry to Germany.