San Domenico (Saint Dominic) is a Baroque-style Roman Catholic church, located on Piazza San Domenico, and located in the ancient quarter of La Loggia, in central Palermo, region of Sicily, Italy.

Piazza San Domenico opens to Via Roma a few blocks south of the large Palazzo delle Poste, and a few blocks north of Sant'Antonio Abate and Teatro Biondo, is the northern border of the warren of alleys of the Vucciria neighborhood.

The cloister, founded by the Chiaramonte family, has column and arches including capitals and spolia from the early 13th century building.

The walls have paintings portraying Dominican saints, scenes of Apocalypse, of the Last Judgement and works by Nicola Spalletta from Caccamo.

The nearby Oratory of Rosario di San Domenico houses also 18th-century decoration and a main altarpiece by Anthony van Dyck.