The Dominican convent was moved in 1407 from its location outside the walls to the houses donated by Doña Guiomar de Meneses.
The cloister of the Silencio contrasts with the Real, of much greater size, that began to build with traces of Covarrubias, in 1541, by his disciple Hernán González de Lara.
The cloister of the Naranjos, also called the Procesiones, underwent a complete transformation in the middle of the 18th century and has reached us with a first floor of arches recessed on columns.
This one began to be constructed in 1587 and it is composed of two spaces: The greater, rectangular, is the one that really serves as sacristy, and another, square, houses a small chapel.
The works of the present church began in 1605 with traces and conditions of Nicolás de Vergara el Mozo.
The naves are separated by three arches with Doric pilasters that support the entablature, on top of which a barrel vault rises.
In the years 1992-1993 important works of remodeling and integration of the convent were realized within the new structures of the University of Castilla-La Mancha, exposing parts of the subsoil of the primitive constructions.