The centered steps are inset within the gallery and lead to the door which is flanked by engaged square columns supporting a full entablature.

The house dates from the arrival of the railroad in DeSoto (c. 1855) and is one of two extant homes that predate the American Civil War there.

[3] Desoto was one of four principle towns, all on the Chickasawhay River and/or along the Mobile and Ohio Railroad, established in Clarke County before the war.

[4] The Cook–Sellers House was listed on the National Register of Historic Places on May 22, 1980, as part of a thematic resource, "Clark County Antebellum Houses".

This article about a property in Mississippi on the National Register of Historic Places is a stub.