The 2001 Copa Libertadores de América was the 42nd edition of CONMEBOL's premier club football tournament.

The winners were Boca Juniors, beating Mexican club Cruz Azul in the finals on penalties and lifting its fourth Copa Libertadores trophy.

If two or more teams are equal on points, the following criteria will be applied to determine the ranking: The top two in each group advanced to the second round.

In the knockout phase, teams played against each other over two legs on a home-and-away basis.

If teams are tied on points and goals after both legs (180 minutes of play), a penalty shootout is carried out.