Adults grow to an average of 5 and 6.5 feet (1.5–2 m)[7] This species exhibits an array of colors and patterns.

The eyes can be yellowish, grayish, or reddish, and they have a reflective membrane that results in eyeshine at night.

"[5] Like all other boas they have a pair of anal spurs that extend from the cloaca, which are small, claw-like remnants of vestigial hindlimbs.

[8][5] Like all other Boidae, Amazon Tree Boas feed by constricting whole, live prey.

In the wild the species has been observed to consume all manner of vertebrate prey, including birds, reptiles, amphibians, mammals and possibly even fish.

After a gestation period of 6–7 months, females give birth from 2–29 young that measure 28.2–64.4 cm in total length.

Surprisingly, though primarily arboreal and nocturnal, Amazon Tree Boas have been documented mating during the day and night as well as in the canopy and on the ground.

[6] While Amazon tree boas are encountered relatively frequently in the pet industry, they have a notoriously irritable temperament, do not hesitate to bite, and have specific care requirements.