[1][2] In 2013, his senior year, he had a 9–4 win–loss record with a 2.23 earned run average (ERA) in 22 appearances.

[7] Burnes made his professional debut with the Arizona League Brewers and was later promoted to the Wisconsin Timber Rattlers.

[16] In the 2018 NLDS against the Colorado Rockies, he pitched four scoreless innings in relief across two appearances, earning the win in the clinching 6–0 Game 3 victory.

[21] On August 12, Burnes tied an MLB record after striking out 10 consecutive batters in a game against the Chicago Cubs.

[22] On September 11, Burnes pitched the first eight innings of a combined no-hitter with Josh Hader against the Cleveland Indians, in which he struck out 14 batters.

On March 22, 2022, Burnes signed a $6.5 million contract with the Brewers, avoiding salary arbitration.

[30] He was a finalist for the NL Gold Glove Award at pitcher, but it was won for the third straight season by Max Fried.

[33] In 32 starts for Milwaukee, he posted a 10–8 record and 3.39 ERA with 200 strikeouts, and was named an All–Star for the third straight season.

[34] On February 1, 2024, the Brewers traded Burnes to the Baltimore Orioles in exchange for DL Hall, Joey Ortiz, and a compensatory draft pick.

[38] The Orioles extended the qualifying offer of $21.05 million for the 2025 season to Burnes, but he declined.

[39] On December 30, 2024, Burnes signed a six-year, $210 million contract with the Arizona Diamondbacks.

[41] During spring training of 2024, Burnes broke out a second curveball, which he throws about 5 miles per hour (8.0 km/h) faster than his first, in strikeout situations.