Cordelia A. Greene (July 5, 1831 – January 28, 1905) was a 19th-century American physician, benefactor, and suffragist from Upstate New York.

Doctor Jabez Greene, well-versed in Hydrotherapy, purchased an inn in Castile from General John D. Landon, and established a medical institute known as "The Water Cure.

Under her father's care, she improved steadily, and after regaining her health, entered the Woman's Medical College of Pennsylvania, in Philadelphia.

Business reverses had come to her father, and by her own efforts in caring for the sick, Cordelia earned the money to pay her college expenses.

After two years of study spent in this college, Cordelia, through the influence of Doctor Henry Foster, of Clifton Springs Sanitarium, obtained an opportunity to assist in a large sanitarium in Cleveland, Ohio, and at the same time pursue her studies in the Western Reserve University.

She was in fellowship with Dr. Foster in his religious views and believed that a strong spiritual atmosphere was a powerful curative agent.

[3] In the summer of 1858, Dr. Greene mother became ill and was carried to Clifton Springs Sanitarium, where after months of care from her daughter, she died.

In discussing future plans, one of the brothers suggested that she should buy the home, "The Water Cure", and there continue her professional work.

[3] Greene published, Build Well: The Basis of Individual, Home, and National Elevation; Plain Truths Relating to the Obligations of Marriage and Parentage, in 1885.

She inserted in the local paper a paid advertisement written from a medical standpoint, showing the harm that comes even to the moderate drinker.

A few weeks before her death, Greene attended the annual convention of the National Woman's Christian Temperance Union (W.C.T.U.

"The Perils of Moderate Drinking", her last brochure, was widely circulated, and her scientific articles on the subject of alcoholic disease were published in leading papers, including the New York Medical Record.

[3] It was an eventful moment in the history of the Castile Town Board when the largest tax payer, Greene, said,— "Gentlemen, taxation without representation is tyranny."

In the spring of 1897, a distinguished trio met in a cottage near the Sanitarium, Susan B. Anthony, Frances E. Willard, and Cordelia A. Greene, to discuss women's suffrage from multiple points of view.

[3] On August 11, 1902, the cornerstone of the Cordelia A. Greene Library was laid,[3] and on December 24, 1902, the new building was formally dedicated.

[3] In 1891, in company with her daughter, Marguerite, she sailed from New York City to San Francisco, making the trip across the Isthmus of Panama.

[3] A part of the winter of 1901, Greene spent in Lyons, her birthplace, in the home of her old school-mate, Marie Rogers Bostwick.