The Coro Synagogue (Spanish: Casa de Oración Hebrea), is a former Jewish synagogue, now museum, located on Talavera Street, in the city of Santa Ana de Coro, Falcón, Venezuela, a city located near the Caribbean Sea coast and the Dutch island of Curaçao.

The former synagogue on Talavera Street was originally built as a house in the first half of the 18th century by the lieutenant governor of Coro Don Francisco Campuzano Polanco as his residence.

Senior's son, Isaac, and his descendants continued living in the Talavera Street house and using one of its rooms as a prayer hall, until the 1880s.

[citation needed] The former synagogue is part of the Alberto Henríquez Museum of Art, which belongs to Universidad Francisco de Miranda.

In 2009, the university contacted the Israelite Association of Venezuela to seek support for the restoration and maintenance of the former synagogue.