The family integrated itself well into the Portuguese nobility in the 17th century through a series of successful marriages and acquisition of several titles, notably Marquis of Castelo Rodrigo.

For the family's service to the crown, João Vaz was made Captain-Donatário (proprietor and governor) of the islands of Terceira and São Jorge, in the Azores.

Gaspar and Miguel's young brother, Vasco Anes II Corte-Real, was nominated also, like his homonym grandfather, alcaide-mor of Tavira, in the early 16th century, accumulating the title with the one inherited from his father as capitain-donatário.

Margarida's son, Manuel de Moura Corte Real, 2nd Marquis of Castelo Rodrigo, amplified the family's position under the Habsburg monarchs of Portugal.

Francisco, who also served as Viceroy of Sardinia, however was the last of the Moura Corte-Real branch of the family before it was exiled from the country due to the Portuguese Restoration War, which saw the Habsburgs deposed in Portugal in lieu of House of Braganza, which expelled supporters of the previous dynasty.