He is best known for his roles as Kenny Lacos in Picket Fences and Mark Hoffman in the Saw films, the former of which earned him two Screen Actors Guild Award nominations.

[2] Mandylor grew up in St Kilda and South Melbourne,[4] and moved to the United States in 1987 where he started taking acting lessons.

He went mentally prepared for the role, telling the Los Angeles Times, "It was interesting that I got that part, because I felt tuned in to gangsters, it was a genre I'd read a lot.

When I was 13, I got a job as a dishwasher in a Melbourne nightclub and saw everything there, real gangsters, and had met characters who were dangerous people from an underground world.

"[5] In 1992, he had a lead role on the CBS television drama, Picket Fences, playing officer Kenny Lacos until the show ended in 1996.