Countess Louise Sophie of Danneskiold-Samsøe (22 September 1796 – 11 March 1867) was a member of a Danish noble family descended illegitimately from Christian V of Denmark, and the wife of Christian August II, Duke of Schleswig-Holstein-Sonderburg-Augustenburg.

[1] Countess Louise Sophie of Danneskiold-Samsøe was born on 22 September 1796 in Gisselfeld, Denmark to Christian Conrad, Count af Danneskiold-Samsøe and his wife Johanne Henriette Valentine Kaas, daughter of the Danish Admiral Frederik Christian Kaas and a descendant of the war hero Jørgen Kaas.

The House of Danneskiold-Samsøe is a non-dynastic branch of the House of Oldenburg, descended from Christian Gyldenløve, Count of Samsø, an illegitimate son of Christian V of Denmark by his mistress Sophie Amalie Moth.

On 18 September 1820 she married her second cousin Christian August II, Duke of Schleswig-Holstein-Sonderburg-Augustenburg at the Church of Braaby, Gisselfeld.

Her descendants include: Auguste Viktoria, German Empress, Queen Frederica of the Hellenes, Constantine II of Greece, Queen Sofía of Spain, Felipe VI of Spain and Carl XVI Gustaf of Sweden.