Louise inherited a vast fortune from her mother, Emilie, Countess von Reichenbach-Lessonitz, the daughter of gold merchant Johann Christian Ortlöpp.

The estate was valued at 48 million marks at the time of her death, an amount equivalent to billions of dollars in today's economy, and was divided equally among Louise and her six surviving siblings.

Count and Countess von Bose established numerous foundations, including a grant of 733,500 goldmarks to Humboldt University, Berlin's oldest institution of higher learning.

They were benefactors of the Senckenberg Natural Research Society in Frankfurt, and the Countess Louise von Bose Foundation funded the creation of the Dental Institute at the University of Marburg.

The Bose Museum on Luisenstrasse (Louise Street) in Kassel is named for her, as is the girls' school (Luisenschule) she established in 1855, and which remains active today.