Together with Louis IX, her husband, she became the most recent common ancestors of all current sovereigns of hereditary monarchies in Europe in 2022 after Charles III became King of the United Kingdom.

Caroline married on 12 August 1741 in Zweibrücken, Louis IX, Landgrave of Hesse-Darmstadt.

She befriended several writers and philosophers of her time, such as Johann Gottfried Herder, Christoph Martin Wieland and Goethe.

She was one of the few women that the Alte Fritz respected, and he famously referred to her as the Glory and Wonder of our century; after Caroline's death, he sent an urn to Darmstadt with the text femina sexu, ingenio vir ('A woman by sex, a man by spirit').

[1] Caroline and her husband became the most recent common ancestors of all reigning hereditary European monarchs in 2022 after Charles III became King of the United Kingdom.