[1] Cardiac rehabilitation services at the hospital are provided by Cheshire and Wirral Partnership NHS Foundation Trust.

[3] By 1948, Chester Royal Infirmary specialized in surgery and out-patients and the City Hospital, Hoole, in chronic illnesses, chest, maternity, paediatric, and general medical cases.

In 1963 a large out-patient and casualty department was opened at the infirmary; this was accompanied with the completion of the Chester inner ring road in 1967.

[6] In April 2014 a new two-storey wing was opened containing a state of the art 21 bed Intensive Care Unit on the first floor, replacing the old HDU and ITU wards.

[7] In August 2023, Lucy Letby, a neonatal nurse who had worked at the hospital several years earlier, was found guilty on seven charges of murder and seven charges of attempted murder following a lengthy trial over the collapses and deaths of babies who were being cared for on the hospital's neonatal ward during 2015 and 2016.

[8] The jury concluded that Letby carried out the attacks by injecting babies with air or insulin, overfeeding them and physically assaulting them with medical equipment.

[10] The ward was downgraded following the final suspicious collapses and deaths over the summer of 2016, resulting in the highest dependency babies no longer being treated there.