[6] Additionally, increased intracranial pressure and movement of cerebrospinal fluid following a trauma may play a role in the injury.
[8] These forces directly disrupt neurons, axons, other neural and meningeal structures, and blood vessels in local or diffuse patterns, typically leading to various cellular, neurochemical and metabolic effects.
[7][10] Closed head injury (coup contrecoup) can damage more than the impact sites on the brain, as axon bundles may be torn or twisted, blood vessels may rupture, and elevated intracranial pressure can distort the walls of the ventricles.
[4] Injuries that occur in body parts other than the brain, such as the lens of the eye,[2] the lung,[14] and the skull[15] may also result from concussion.
In 1768, the group met again on the topic, and Louis Sebastian Saucerotte won the prize for his paper describing contrecoup injuries in humans and experiments on animals and recommending treatments such as bloodletting and application of herbs to patients' heads.