The Courthouse Square Historic District is a national historic district located at Farmington, St. Francois County, Missouri.

It developed between about 1871 and 1954, and includes representative examples of Greek Revival, Gothic Revival, Late Victorian, Beaux Arts, and Bungalow / American Craftsman style architecture.

Located in the district is the separately listed St. Francois County Jail and Sheriff's Residence.

Other notable buildings include the St. Francois County Courthouse (c. 1926), Rottger Building (c. 1904), Gierse Tailor Shop (c. 1876), Long Memorial Hall (1924), Methodist Episcopal Church (c. 1904), Masonic Temple (c. 1911), and Fitz Building (c.

This article about a property in St. Francois County, Missouri on the National Register of Historic Places is a stub.