Craig's Wife premiered on Broadway at the Morosco Theatre on October 12, 1925, and closed on August 21, 1926, after 360 performances.

The Pulitzer committee wrote, "Craig's Wife has been selected by the jury on account of the dignity of its theme, the soundness of its construction, the excellence of its dialogue, and its effectiveness in the theater.

The 1928 silent version was directed by William C. deMille, Cecil's brother, and starred Irene Rich in the title role.

Cecil B. deMille produced Craig's Wife on the Lux Radio Theatre in Hollywood in 1936.

Orson Welles's The Campbell Playhouse performed the play on CBS Radio, airing March 10, 1940.