At the end of his career, he ranked sixth in NL history in games played (2,850), fifth in at bats (10,876), 21st in hits (3,060), and seventh in runs scored (1,844).

A four-time Gold Glove Award winner who led NL second basemen in assists six times and putouts five times, he retired ranking fourth in NL history in games at second base (1,989), sixth in assists (5,448) and fielding percentage (.984), seventh in putouts (3,992) and double plays (1,153), and eighth in total chances (9,596).

Biggio, Vaughn and Valentin, along with Marteese Robinson, were featured in the book The Hit Men and the Kid Who Batted Ninth by David Siroty, which chronicled their rise from college teammates to the major leagues.

Biggio remains Seton Hall's leader in triples, second in runs scored, and is in the top 10 in 18 other single-season and career categories.

Astros management, in an attempt to keep the rigors of catching from sapping Biggio's speed, tried him in the outfield part-time in 1990, as he had played 18 games there in the minors.

Yogi Berra mentioned Biggio's height in his book You Can Observe A Lot By Watching, saying, "I always identified with short catchers—they don't have to stand up as far".

[5] The Astros acquired first baseman Jeff Bagwell prior to the start of the 1991 season, who, like Biggio, spent his entire major league career with Houston.

A prodigious offensive and defensive unit, during their 10 peak seasons from 1994 to 2003, they appeared in nine All-Star Games, won five Gold Gloves, ranked in the top five of the Most Valuable Player Award voting five times and averaged 226 runs scored.

[11] His statistics reflect this, having consistently good marks in hitting, on-base percentage, hit-by-pitch, runs, stolen bases, and doubles throughout his career.

Biggio played 1,800 games without a trip to the disabled list until August 1, 2000, when he suffered a season-ending knee injury.

Biggio rebounded with a good season in 2001, but had a lackluster performance in 2002, with only a .253 average, his lowest since entering the league; a highlight occurred on April 8, when he hit for the cycle for the only time in his career.

However, he improved slightly for the 2003 season, averaging .264 with 166 hits despite being asked by management to move to center field after the signing of free agent All-Star second baseman Jeff Kent.

Biggio moved to yet another new position, left field, midway through the 2004 season to accommodate Beltrán, who was acquired in a trade to help bolster the Astros' struggling offense.

Having fired Jimy Williams for Phil Garner, the Astros went 48-26, which included a 36-10 stretch to end the year while narrowly clinching the NL wild card on the final day of the regular season.

[20] After having played 4,714 games and their entire major league careers together in Houston, Biggio and Bagwell appeared in their first and only World Series that year[21] against the Chicago White Sox.

The White Sox swept the Astros to secure the championship[22] with the lowest run-scoring differential in a World Series sweep.

On June 28, 2007, Biggio became the 27th player in the history of Major League Baseball to join the 3,000 hit club, with a single against Colorado Rockies pitcher Aaron Cook.

Incidentally, this also caused him to fall short of the 3,000 hits, 300 homers and 300 stolen bases mark; he would have been only the second player in history to reach that club, the other being Willie Mays.

Hours later, with the Astros locked in a 3–3 tie with the Los Angeles Dodgers, Biggio hit a grand slam in the 6th inning.

[26] A sellout, record-breaking crowd packed Minute Maid Park on September 30, 2007, to witness Biggio's final game.

In his final career at-bat, he grounded the ball to third baseman Chipper Jones, who threw out the hustling Biggio by half a step.

[28] On June 29, 2005, Biggio broke the modern-era career hit-by-pitch record, previously held by Don Baylor with 267.

In August 2007, the satirical online newspaper The Onion referenced this in the article "Craig Biggio Blames Media Pressure For Stalling at 285 Hit-By-Pitches".

[30] Biggio sent an arm guard to the National Baseball Hall of Fame in recognition of his high hit-by-pitch total.

The Roberto Clemente Award "recognizes the player who best exemplifies the game of baseball, sportsmanship, community involvement and the individual's contribution to his team".

This edict was big news in Houston, and Houstonians, long known for their charitable nature and unconditional love of Biggio, reacted very negatively to MLB.

After the public uproar, MLB relented and Biggio was allowed to wear the Sunshine Kids pin as he had done since becoming a spokesperson.

[41] Biggio coached St. Thomas to back-to-back Texas Association of Private and Parochial Schools (TAPPS) Class 5A state baseball titles in 2010 and 2011.

Cavan hit a home run in the team's 2011 championship game, while older brother Conor provided the winning offense in St. Thomas' semifinal victory.

[43] Biggio's father-in-law is former Assemblyman Joseph V. Egan, who was a longtime member of the New Jersey legislature until his 2024 retirement at age 86.