[1] Zisk grew up in Dallas, where he graduated from the St. Mark's School of Texas.
[2] After graduating from the University of Southern California, Zisk directed his first television series, Brooklyn Bridge, at the age of 26.
His first feature film was The English Teacher, starring Julianne Moore, Greg Kinnear, Nathan Lane, Michael Angarano and Lily Collins.
[3] Zisk has executive-produced several series including Weeds, United States of Tara and The Larry Sanders Show.
He has also directed over 50 series, including The Big C, Nurse Jackie, Entourage, The Office, Alias, Smash, Parks and Recreation, Shameless, Nip/Tuck, The Exorcist, New Amsterdam, Brave New World, and Halo.