Craniometaphyseal dysplasia is a rare skeletal disorder that results from a mutation in the ANKH or GJA1 genes.

The condition is characterized abnormal facial features, impairment of cranial nerves, and malformation of the long bones in the limbs.

Some things such as cranial base sclerosis and nasal sinuses obstruction can be seen during the beginning of the child's life.

In radiographic findings the most common thing that will be found is the narrowing of foramen magnum and the widening of long bones.

[citation needed] The only treatment for this disorder is surgery to reduce the compression of cranial nerves and spinal cord.