Crazy House is notable for its impressive cast of supporting comedians (Percy Kilbride, Cass Daley, Shemp Howard, Edgar Kennedy, Franklin Pangborn, Billy Gilbert, Richard Lane, Andrew Tombes, Chester Clute, and Hans Conried) and guest stars under contract to Universal at the time (Allan Jones, Basil Rathbone and Nigel Bruce, Robert Paige, Leo Carrillo, Johnny Mack Brown, and Andy Devine).

Financed by an eccentric "angel", the completed feature is set to premiere when angry creditors confiscate most of the film.

Olsen and Johnson keep the preview going anyway and their venture is a success; but only because the team gives the president of their former studio a hotfoot to trick him into standing up and "bidding" for the film.

The team's wild style of comedy had always been a matter of taste, more for "plain folks" than sophisticates, and contemporary exhibitor reports ran the gamut: "Just made for small towns.

However, the high budget cut into the profit margin, so Universal economized on Olsen & Johnson's next two features, Ghost Catchers and See My Lawyer.